The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013Evaluation of a LRRK2 Inhibitor in the Partial 6-OHDA-lesioned Model of Parkinson’s Disease
Objective/Rationale:
Mutations in the LRRK2 gene are the most common cause of familial Parkinson’s disease (PD). The existing human genetic, cell-based and model data suggest that LRRK2 kinase... -
Research Grant, 2013Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease
Objective/Rationale:
The age of onset and penetrance (likelihood of disease) of individuals with the LRRK2 G2019S mutation varies considerably, the latter ranging in some families from as high as 100... -
Cognition Biomarkers, 2014miRNA Markers of Cognition
Objective/Rationale:
In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs... -
Cognition Biomarkers, 2013Validation of Novel and Traditional Quantitative EEG Biomarkers
Objective/Rationale:
Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD... -
LRRK2 Challenge, 2013Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
Objective/Rationale:
Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the... -
Parkin Biology, 2014Role of Parkin in Innate Immunity
Objective/Rationale:
The protein Parkin contributes to the elimination of damaged mitochondria by a process called mitophagy. Prior research has shown that silencing Parkin gene affects innate immunity...
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Our funding programs support basic, translational and clinical research from academia and industry.