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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2011
    Targeting Beta-arrestin Signaling in the Treatment of Parkinson's Disease

    Objective/Rationale:
    Beta-arrestins were originally identified as proteins that attenuate the signaling function of the large class of receptors to which dopamine receptors belong. However, recently...

  • Defining Cognitive Phenotypes of Parkinson's Disease, 2011
    Cognitive Phenotypes in Parkinson's Disease: Anatomical and Functional Correlates

    Objective/Rationale:
    Cognitive impairment with and without dementia is frequent in Parkinson's disease (PD). However, there is a high heterogeneity in the clinical presentation of these cognitive...

  • Defining Cognitive Phenotypes of Parkinson’s Disease, 2011
    Bioanatomical Phenotype of Parkinson's Disease With and Without Cognitive Impairment

    Objective/Rationale:             
    Mild cognitive impairment (MCI) and dementia are common in Parkinson’s disease. However, presently, it is difficult to recognize which aspects of cognitive changes are...

  • Improving Levodopa Delivery, 2011
    Continuous Subcutaneous Levodopa Prodrug Infusion

    Objective/Rationale:
    Numerous studies demonstrate that continuous levodopa infusion can result in reductions of more than 50 percent in time spent in the "off" state and time spent with severe...

  • Target Validation, 2011
    Caspase-8 Control Microglia Activation and Neurotoxicity in Parkinson's Disease

    Objective/Rationale:
    Sustained microglia activation and resulting neuroinflammation is believed to play an important role in the mechanism of chronic dopaminergic neuronal loss in Parkinson’s disease...

  • MJFF Research Grant, 2011
    Development of Highly Sensitive and Specific Antibodies Against Oxidized DJ-1 as a Biomarker for Parkinson's Disease

    Objective/Rationale:
    Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be lower in the CSF of sporadic PD compared to controls. DJ-1...

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