The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2019Investigating Vulnerability of Subsets of Dopaminergic Neurons
Study Rationale:
Brain cells that produce the neurotransmitter dopamine are the most vulnerable to cell death in Parkinson’s disease (PD), but the reasons for this are not known. New techniques have... -
Research Grant, 2019Parkinson’s Digital Biomarker DREAM Challenges to Develop Measures of Symptoms and Severity
Study Rationale:
The use of wearable sensors to detect and measure Parkinson’s disease shows great promise. However how to convert the raw data to specific measures is poorly understood. We propose a... -
Access to Data and Biospecimens, 2019Convergence of LRRK2 and GBA in the Pathogenesis of Parkinson’s Disease Supplement
Promising Outcomes of Original Grant:
In our original project we used dopamine cells derived from induced pluripotent stem cells (iPSCs) from people with Parkinson’s-associated LRRK2 or GBA mutations... -
Research Grant, 2019Determining the Level of LRRK2 Inhibition Required for Therapeutic Efficacy
Study Rationale:
While inhibitors of LRRK2 activity are currently in clinical trials for the treatment of Parkinson’s disease, the minimum requirement of target engagement to significantly modify... -
Target Advancement Program, 2019Targeting Necroptosis to Stop Axonal Degeneration in Parkinson's Disease
Study Rationale:
Parkinson’s disease (PD) is caused by degeneration of dopamine neurons. Neurons are constituted by a cell body and projections called axons by which neurons communicate... -
Target Advancement Program, 2019GBA Stabilization through Nanobodies
Study Rationale:
Mutations in the GBA gene are a known genetic risk factor for Parkinson’s disease and cause reduced stability and activity of the GBA protein. This can contribute to the impairment of...
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Our funding programs support basic, translational and clinical research from academia and industry.