The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2020Quantification of S129 Phosphorylated Alpha-Synuclein Using the AlphaLISA Immunoassay Platform
Study Rationale:
In Parkinson's, there remains an unmet need for biomarkers to track disease progression and efficacy of potential therapies. This team of investigators is focused on fluid-based... -
Access to Data and Biospecimens, 2020Development of a Biomarker Platform for Parkinson’s Disease Using Patient-derived Cells
Study Rationale:
Inadequate understanding of how Parkinson's disease develops is a major roadblock in developing effective therapeutics and methods to diagnose the disease earlier. This project... -
Improved Biomarkers and Clinical Outcome Measures, 2020PPMI DATIQ and SR T1w MRI Analysis
Study Rationale:
Parkinson’s disease results in functional and structural changes in the brain. Non-invasive imaging methods such as SPECT and MRI can measure these changes. The dopamine transporter... -
Improved Biomarkers and Clinical Outcome Measures, 2020Predicting Conversion to Parkinson’s Disease Based on Proteomic Biomarkers in a Large Prospective Cohort
Study Rationale:
The ultimate aim in Parkinson’s disease research is to identify individuals at risk for developing Parkinson’s prior to disease onset. To reach this goal, a set of informative markers... -
Improved Biomarkers and Clinical Outcome Measures, 2020Assessment of Brain Tau Burden in Parkinson's Disease with or without a LRRK2 Mutation using [18F]MK-6240 PET Imaging
Study Rationale:
The precise mechanisms of cellular damage in Parkinson's disease remain unclear. Research has shown that abnormal forms of the protein alpha-synuclein accumulates in brain cells in... -
Research Grant, 2020Targeting TNFR2 in a Model of Parkinson’s Disease
Study Rationale:
In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous...
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Our funding programs support basic, translational and clinical research from academia and industry.