The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Analysis of Patient-Reported Outcomes from Fox Insight, 2021Characterizing Impairment Trajectories in People with Parkinson’s Disease
Study Rationale:
Little is known about what causes individuals with Parkinson’s disease (PD) to develop symptoms, much less the genetic and non-genetic factors that influence these changes. In most... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease
Study Rationale:
We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This... -
Therapeutic Pipeline Program, 2021Targeting Brain-specific Stearoyl-CoA-Desaturase 5 (SCD5) as a Treatment for Parkinson’s Disease
Study Rationale:
Previous studies have shown that fat molecules called unsaturated fatty acids regulate the harmful effects that alpha-synuclein have on neurons. This protein forms a key part of Lewy... -
Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Use of Itaconate to Improve Metabolic Regulation in Parkinson's Disease
Study Rationale: In people with Parkinson’s disease (PD), chronic inflammation and metabolic reprogramming triggers neuronal cell death. Impaired function of the proteins involved in cellular...
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Fall 2021 RFP: Expanding Biological Understanding of PD, 2022Identifying a Molecular Signature of DNA Damage in the Blood Cells of People with Parkinson’s Disease
Study Rationale: The instructions needed to govern the function of living things are stored in their cells’ DNA. In cell types that divide, such as blood or skin, DNA checked for damage and repaired...
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Fall 2021 RFP: Expanding Biological Understanding of PD, 2022Examining Fatty Acid Imbalances in Parkinson’s Disease
Study Rationale: In people with Parkinson’s disease (PD), alpha-synuclein proteins aggregate to form structures called Lewy Bodies (LBs). These LBs have recently been found to also contain lipid...
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Our funding programs support basic, translational and clinical research from academia and industry.