The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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The Role of Inflammation in Parkinson's Disease, 2004The role of TNF-mediated dopaminergic neurotoxicity in Parkinson's disease: Novel anti-TNF biologics as biochemical tools and new therapeutic agents
In July 2004, at the one-year assessment of our initial grant under the Foundation's Inflammation initiative, we demonstrated that our novel dominant-negative TNFs offered significant in vivo...
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The Role of Inflammation in Parkinson's Disease, 2005Development of a Dominant-Negative TNF Lentiviral Approach
Because TNF inhibitors are not believed to cross the blood-brain barrier, an orally administered TNF-based therapy is not currently possible. The Foundation has awarded supplemental funding to drive...
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Target Validation, 2007Development of Lentiviral DN-TNF Vectors: A Novel Anti-inflammatory Gene Therapy to Block Nigrostriatal Degeneration
Objective/Rationale:
A growing number of epidemiological and experimental animal studies implicate neuroinflammatory mechanisms in the progressive death of midbrain dopamine (DA) neurons in Parkinson’s...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2006Generation of Midbrain Dopamine Neurons from Human ES Cells by Forced Expression of Lmx1a
Drs. Ericson and Perlmann have identified two key transcription factors (Lmx1a and Msx1) that regulate early development of dopamine neurons and can induce nearly 90% ‘authentic’ dopamine neurons when...
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Clinical Intervention Awards, 2007Serotonin and Sleep Disordered Breathing in Parkinson Disease
Objective/Rationale:
Sleep related problems are a major cause of impairment in Parkinson's disease. Recent studies indicate a high incidence of a disabling sleep disorder – sleep disordered breathing... -
Clinical Intervention Awards, 2007The PARKFIT Study: Effectiveness of an Active Lifestyle Promotion Program for Patients with Parkinson’s disease
Objective/Rationale:
Parkinson's patients are inclined toward a sedentary lifestyle. This is due to a combination of both physical handicaps (e.g. walking difficulties) and mential impairments (e.g...
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Our funding programs support basic, translational and clinical research from academia and industry.