The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013LRRK2 Role on Auto-antibody Production by Human B Cells
Objective/Rationale:
B lymphocytes are cells of the immune system that have a dual function: they produce antibodies to fight disease-causing agents, and they participate in the... -
LRRK2, 2011LRRK2 Role on Auto-Antibody Production by Human B Cells
Objective/Rationale:
LRRK2 expression has been demonstrated in the brain and several organs, including the thymus and spleen, which are major immune system organs for B and T lymphocyte maturation... -
Rapid Response Innovation Awards, 2011Ability of a Mitochondria Improver, Berberine, to Attenuate Parkinson's Disease
Objective/Rationale:
Mitochondrial dysfunction is a central modification underlying the damage of dopamine neurons in Parkinson’s disease (PD). Our hypothesis is that drugs able to stabilise... -
Rapid Response Innovation Awards, 2010Deciphering the Molecular Effects of Alpha-Synuclein in the Nucleus: DNA Binding and Transcriptional Dysregulation
Objective/Rationale:
A-synuclein, the main component of Lewy bodies, is thought to be present mostly on nerve terminals. Although the function of a-synuclein is unclear, its presence in the nucleus of... -
Rapid Response Innovation Awards, 2008Unraveling the Genetic Basis for Alpha-Synuclein Oligomerization in Living Cells Using Bimolecular Fluorescence Complementation
Promising Outcomes of Original Grant:
The formation of large alpha-synuclein protein inclusions in the brain is the pathological hallmark of Parkinson’s disease but whether those inclusions are the... -
Rapid Response Innovation Awards, 2007Unraveling the genetic basis for alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation
Oligomerization of alpha-synuclein is hypothesized to be the pathogenic mechanism of protein aggregate formation and cell death in neurons of PD patients. Dr. Outeiro proposes to develop an assay to...
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Our funding programs support basic, translational and clinical research from academia and industry.