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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2013
    A Study to Evaluate Feasibility, Safety and Preliminary Efficacy of Magnetic Resonance Image Guided Focused Ultrasound for the Treatment of Parkinson’s Disease Dyskinesia

    Objective/Rationale:             
    The effectiveness of drug therapy to alleviate Parkinson’s disease (PD) symptoms often diminishes over time, and side effects such as dyskinesia (involuntary...

  • MJFF Research Grant, 2013
    Transcutaneous Submandibular Gland Biopsy: A Diagnostic Test for Early Parkinson’s Disease

    Objective/Rationale:             
    We have previously found that in autopsied patients with Parkinson’s disease (PD) the hallmark finding in the brain (Lewy-type alpha synuclein staining or LTS) is...

  • Target Validation, 2012
    Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease

    Objective/Rationale: 
    Parkinson’s disease (PD) involves inappropriate activation of the immune system.  Cytokines activate immune cells by engaging the JAK/STAT pathway, which receives signals from...

  • MJFF Research Grant, 2012
    The Role of Amyloid in the Progression of Cognitive Impairment in PD: A Prospective Cohort Study

    Objective/Rationale:             
    Dementia is a frequent and devastating non-motor complication of Parkinson's disease (PD). Although loss of dopamine producing brain cells play a role in cognitive...

  • Target Validation, 2012
    Evaluation of the Microtubule-Stabilizing Agent, Epothilone D, in Mouse Models of Parkinson's Disease

    Objective/Rationale:             
    Microtubules are critical components within nerve cells, where they serve as the “railroad” tracks upon which cellular cargo is transported up and down the length of...

  • Rapid Response Innovation Awards, 2013
    Neuromelanin in Circulating Phagocytes May Reveal Early Neurodegeneration in Parkinson’s Disease

    Objective/Rationale:             
    A normal function of inflammation is to recruit phagocytic white blood cells (think PACMAN) to clear away the damaged cells. We postulate that debris laden PACMEN re...

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