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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Understanding LRRK2 Biology, 2009
    LRRK2 Mediated Pathogenic Pathways in Dopaminergic Axonal Degeneration and Synaptic Transmission

    Objective/Rationale
    Mutations in the LRRK2 gene occur with high frequency in familial and sporadic Parkinson disease.  We have established a R1441G-LRRK2 transgenic pre-clinical model that...

  • Understanding LRRK2 Biology, 2009
    Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale
    Mutations in the LRRK2 gene are a common cause of familial and sporadic Parkinson’s disease. The LRRK2 protein can function as a kinase in vitro and certain familial mutations may...

  • Understanding LRRK2 Biology, 2009
    Functional Analysis of LRRK2

    Objective/Rationale
    LRRK2 is a gene that, when not working properly, causes Parkinson’s disease. However, the function of this large gene and its involvement in the disease process is virtually...

  • Understanding LRRK2 Biology, 2009
    Development of Biochemical Assays for LRRK1

    Objective/Rationale
    Studies over the last several years have identified the protein kinase LRRK2 as a potential target for Parkinson’s disease therapeutics.  While targeting kinases has been a...

  • Biomarkers, 2009
    T-Cell Receptors Changes as a Biomarker of Parkinson's Disease

    Objective/Rationale:
    The diagnosis of PD is based on clinical characteristics because there are no reliable blood tests for early diagnosis or to follow the progressive course of the disease. Along...

  • Target Validation, 2009
    Testing PDE-1 Inhibitor in MPTP-treated Macaques

    Promising Outcomes of Original Grant:
    Our goal is to develop novel therapeutic molecules that promote normal dopamine neurotransmission in the brain affected by PD. We hypothesize that these molecules...

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