The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Isoform Specific Suppression of dIRE-SNCA with an ASO
Study Rationale: Alpha-synuclein (SNCA) aggregation is a hallmark of Parkinson’s disease (PD). Rare SNCA genetic duplications and triplications cause early-onset PD, suggesting a link between SNCA...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Next Generation Treg Therapy for Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) occurs because of the degeneration of the neurons that produce the neurotransmitter dopamine. This causes the disease signs and symptoms. Nerve cell...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Lead Optimization of a B1-selective AMPK-activator for Treatment of PD
Study Rationale: Overwhelming evidence indicates that mitochondrial dysfunction contributes to the development of Parkinson’s disease (PD). We have shown that activating the enzyme AMPK prevents...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Novel Small Molecules to Slow PD Progression in a Genetically Defined Subset of People with PD
Study Rationale: Currently, drug discovery efforts for neurodegeneration are almost exclusively focused on disease risk, not the progression biology that afflicts patients when they present with...
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Research Grant, 2025Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD.
Study Rationale: Sometimes, a "typo" in a gene called LRRK2 increases the risk of Parkinson's disease (PD), leading to a distinct PD version called LRRK2-PD. While people with LRRK2-PD maintain good...
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Research Grant, 2025Validation of the Usability of Patient-specific Midbrain Organoids for LRRK2 Drug Discovery in Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is a progressive brain disorder characterized by the loss of dopamine-producing neurons. OrganoTherapeutics has developed advanced midbrain organoid models...
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Our funding programs support basic, translational and clinical research from academia and industry.