The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2014Rating Segmental Progression of Cardinal Motor Symptoms in Early Parkinson's Disease
Objective/Rationale:
We recently reported a new, practical approach to rate segmental progression of cardinal motor symptoms in Parkinson's disease (PD) at early stages. We computed four new scores —... -
Research Grant, 2013Comprehensive Structural and Molecular Phenotyping of Parkinson’s Disease Models
Objective/Rationale:
Parkinson’s disease (PD) pre-clinical models carrying relevant human PD gene mutations can provide important insights into the molecular mechanisms implicated in PD... -
Access to Data and Biospecimens, 2014Contribution of the Unfolded Protein Response to Idiopathic and LRRK2-driven Parkinson’s Disease
Objective/Rationale:
The unfolded protein response (UPR) is a life-death switch that instructs aged and overworked cells to self-destruct. We hypothesize that hyper-activation of the UPR... -
Research Grant, 2015Investigation of SNCA Mosaicism in Brain in Parkinson's Disease
Objective/Rationale:
In most cases, the cause of Parkinson’s disease (PD) is unknown. Testing blood for genetic mutations (DNA changes) known to cause PD is usually negative, particularly... -
Target Validation, 2015Utilizing Transcriptional Pathways to Enhance Mitochondrial Health in Models of Parkinson’s Disease
Objective/Rationale:
Neurons of the substantia nigra are particularly vulnerable to cell death in Parkinson’s disease (PD). One potential contributing factor is dysfunction of mitochondria... -
Therapeutic Pipeline Program, 2014Restoring the Nigrostriatal Pathway with Living Micro-Tissue Engineered Axonal Tracts
Study Rationale:
By the time Parkinson’s disease (PD) symptoms appear, typically 60% of neurons in the substantia nigra and their axonal projections (nerve fibers) to the striatum...
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Our funding programs support basic, translational and clinical research from academia and industry.