The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biomarkers, 2024Development and Validation of a Sensitive Method for Measuring PRKN
Study Rationale: Mutations in the genes encoding PRKN and PINK1 are associated with Parkinson’s disease (PD). PINK1 and PPKN proteins work together to mediate the degradation of damaged mitochondria...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024A Clinical Trial to Investigate the Safety of Repeated Subcutaneous Injections of HER-096, a Novel Candidate for Disease-modifying Therapy in Parkinson’s Disease
Study Rationale: sHER-096 is a novel compound that mimics CDNF, a human neurotrophic factor that has shown neuroprotective and neurorestorative properties in an animal model of Parkinson’s disease (PD...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Therapeutic Development of Novel STING Inhibitors to Treat Parkinson's Disease Neuroinflammation
Study Rationale: Brain inflammation plays an important role in the pathology and progression of Parkinson’s disease (PD). One of the key proteins involved in this inflammatory process is STING...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Use of the Dual-action Neuroprotective Compound KLS-13019 to Treat Motor Impairment in a Preclinical Model of Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is associated with a loss of mitochondrial function and increased inflammation. A dual-action drug candidate, KLS-13019, both protects mitochondria from...
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Seed Amplification Assay Innovation Program, 2025Quantitative SAAs for Alpha-synuclein from Various Matrices
Study Rationale: Currently existing seed amplification assays (SAAs) in which pathological protein clumps from patient samples are amplified such that they can be more easily detected for the...
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T2T Validation - NOD2, 2025Using Knowledge Graphs to Predict NOD2 Directionality for Therapeutic Effect in Parkinson’s Disease
Study Rationale: NOD2 is a key component of our immune defense system that detects invading pathogens and promotes their removal. Under healthy, ideal circumstances, NOD2 activity has a ‘Goldilocks...
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Our funding programs support basic, translational and clinical research from academia and industry.