The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Novel Hypotheses in Parkinson's Disease, 2010Quantitative Analysis of S-Nitrosylated Proteins in Parkinson's Disease
Objective/Rationale:
Free radical stress may play a role in pathogenesis of Parkinson’s disease (PD). In this project, we study how free radicals related to reactive nitrogen (N) and oxygen (O)... -
Understanding LRRK2 Biology, 2010Functional Analysis of LRRK2: Focus on Autophagy
Promising Outcomes of Original Grant:
The overall purpose of the original grant was to utilize pre-clinical and human model systems to better understand LRRK biology. The original aims proposed were to... -
Neurotrophic Factor Therapies for Parkinson's Disease, 2010CDNF (Cerebral Dopamine Neurotrophic Factor) for Therapy of Parkinson's Disease
Objective/Rationale:
CDNF protein is expressed in human brain, acts differently from known neurotrophic factors and can protect and repair dopamine neurons in two pre-clinical models of Parkinson’s... -
Target Validation, 2009Testing PDE-1 Inhibitor in MPTP-treated Macaques
Promising Outcomes of Original Grant:
Our goal is to develop novel therapeutic molecules that promote normal dopamine neurotransmission in the brain affected by PD. We hypothesize that these molecules... -
Rapid Response Innovation Awards, 2010Selective Neuroprotective Effects of the S18Y Polymorphic Variant of UCH-L1
Promising Outcomes of Original Grant:
We were able to replicate in an in vivo setting in the nigrostriatal system our previous observation in neuronal cell cultures that lack of UCH-L1 did not alter... -
Rapid Response Innovation Awards, 2010Ghrelin - a Peripheral, Preclinical Biomarker for Parkinson's Disease
Promising Outcomes of Original Grant:
In our original grant we investigated serum concentrations of the hormone ghrelin in the fasting state and at different time points after a standardized test meal...
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Our funding programs support basic, translational and clinical research from academia and industry.