The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2023(SUPPLEMENT) The Foundational Data Initiative
Study Rationale: This project aims to produce foundational data that will provide a resource for understanding the molecular basis of Parkinson’s disease (PD). The work, conducted in cells collected...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Characterization of a Novel Strategy to Target LRRK2 and Its Downstream Signaling Pathway
Study Rationale: Genetic mutations that activate LRRK2 are linked to familial Parkinson’s disease (PD). However, no clinically approved inhibitors for LRRK2 currently exist. In this study, we will...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Examining a Novel GCase Activator in Neurons Derived from People with Parkinson’s Disease
Study Rationale: Decreased function of the lysosomal enzyme GCase is associated with Parkinson’s disease (PD). We discovered that LIMP-2, the protein that transports GCase to the lysosome, also...
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Research Grant, 2023(SUPPLEMENT) Development of an Imaging Tracer for Measuring Alpha-synuclein
Study Rationale: The discovery of new treatments for Parkinson’s disease (PD) has been hampered by the amount of time it can take (typically a number of years) to determine whether a drug works in a...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Structure and Mechanism of PINK1-TOM Supercomplex Formation
Study Rationale: Mitochondrial dysfunction plays an important role in the development and progression of Parkinson’s disease (PD). In healthy cells, when mitochondria become damaged, protein called...
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Lysosomal Biomarkers Program, 2023Validating Measurements of Peripheral GCase Longitudinally Under Clinical Trial Conditions
Study Rationale: An enzyme known as GCase is a key protein that stops working properly in people with Parkinson’s disease (PD). However, determining exactly how impaired the enzyme’s activity might...
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Our funding programs support basic, translational and clinical research from academia and industry.