The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Lysosomal Biomarkers Program, 2023Development of Autophagy-lysosome Biomarkers for Parkinson’s Disease Using Stem Cell-derived Neurons and Biofluids
Study Rationale: Genetic, molecular, and pathological studies have highlighted the role of dysfunctional mechanisms for clearing cellular debris — called autophagy-lysosome pathways — in the...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Evaluating the Impact of LRRK2 Mutation on Lysosomal Function in Macrophages
Study Rationale: Mutations in LRRK2 are associated with inherited forms of Parkinson’s disease (PD). LRRK2 is a lysosomal protein that is produced in immune cells, such as macrophages. These cells are...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Targeting the Blood-brain Immune Axis to Prevent Progression of Parkinson’s Disease
Study Rationale: Recent studies suggest that the barrier that separates the brain from the rest of the body, including the blood, might become dysfunctional over the course of Parkinson’s disease (PD)...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Investigating the Molecular Basis of Neurodegeneration in GBA-associated Parkinson's Disease
Study Rationale: Mutations in GBA1, the gene that encodes the enzyme glucocerebrosidase (GCase), are among the most common genetic risk factor for the development of Parkinson’s disease (PD). GCase...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023SUPPLEMENT | CMA as a Means to Counteract Alpha-synuclein Pathology in Non-human Primates”
Study Rationale: One of the main pathways to remove excess amounts of the alpha-synuclein protein that is linked to Parkinson’s disease (PD) is the lysosomal chaperone-mediated autophagy (CMA) pathway...
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Research Grant, 2023Establishing the South Carolina Parkinson’s Disease Registry
Study Rationale: The South Carolina Parkinson’s Disease (PD) Registry aims to collect data on the incidence and prevalence of PD in the state. Established by South Carolina Parkinson's Disease...
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Our funding programs support basic, translational and clinical research from academia and industry.