The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016Further Validation of SIRT3 in a Parkinsonian Model
Objective/Rationale:
Dysfunctional mitochondria (powerhouses of the cell) are central to the pathology of Parkinson's Disease (PD). Sirtuins are a group of proteins that increase energetic processes... -
Research Grant, 2016Validation of Uncharacterized LRRK2 Phosphorylation Sites
Study Rationale:
The Parkinson's disease (PD) protein kinase (enzyme) LRRK2 is regulated by a chemical process called phosphorylation. To date, only a handful of the sites of phosphorylation have been... -
Target Advancement Program, 2016Characterization of TNIK as a LRRK2 Kinase
Study Rationale:
The LRRK2 protein undergoes chemical modification called phosphorylation, which can alter its function, and is carried out by enzymes called kinases (LRRK2 is also a kinase)... -
Target Advancement Program, 2016High-throughput LRRK2 Ubiquitination Assay
Study Rationale:
The LRRK2 protein is regulated by modifications called phosphorylation, which occurs at several specific sites on the protein (Serines910, 935, 955, 973) and can alter the biology of... -
Biomarkers Across Neurodegenerative Diseases, 2016Network Models of Neurodegeneration (NetMON)
Study Rationale:
The global aging population has placed neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, among the biggest public health challenges of 21st century healthcare. It is...
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Research Grant, 2016Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking
Promising Outcomes of Original Grant:
Our previous work provided evidence that LRRK2 plays a crucial role in neurons by affecting the trafficking (movement across the cell) of synaptic vesicles...
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Our funding programs support basic, translational and clinical research from academia and industry.