The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2012Intrinsic Remodeling of the Fovea in Parkinson’s Disease
Promising Outcomes of Original Grant:
In the past we determined the part of the retina (the back of the eye) which needs to be measured for PD induced changes. We developed an equation which permits... -
MJFF Research Grant, 2012Bay Area Solvent Study - Symptoms (BASS-S)
Objective/Rationale:
Chlorinated solvents are commonly used in a variety of occupations. The solvents trichloroethylene (TCE) and perchloroethylene (PERC) have been associated with an... -
Research Grant, 2012Phase I-B Clinical Trial of AVE8112 for Cognitive Impairment in Parkinson’s Disease
Objective/Rationale:
Cognitive impairment is a symptom seen in Parkinson’s disease (PD) patients, and some can progress to dementia. AVE8112 is a PDE4 inhibitor that was in development by the... -
Target Validation, 2012Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease
Objective/Rationale:
Parkinson’s disease (PD) involves inappropriate activation of the immune system. Cytokines activate immune cells by engaging the JAK/STAT pathway, which receives signals from... -
MJFF Research Grant, 2012The Role of Amyloid in the Progression of Cognitive Impairment in PD: A Prospective Cohort Study
Objective/Rationale:
Dementia is a frequent and devastating non-motor complication of Parkinson's disease (PD). Although loss of dopamine producing brain cells play a role in cognitive... -
Target Validation, 2012Evaluation of the Microtubule-Stabilizing Agent, Epothilone D, in Mouse Models of Parkinson's Disease
Objective/Rationale:
Microtubules are critical components within nerve cells, where they serve as the “railroad” tracks upon which cellular cargo is transported up and down the length of...
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Our funding programs support basic, translational and clinical research from academia and industry.