The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016Modelling LRRK2 Structure and Characterizing the LRRK2 Activation Cycle in LRRK2-mediated Parkinson's disease
Promising Outcomes of Original Grant:
We modelled the three-dimensional structure of full-length leucine rich repeat kinase 2 (LRRK2) using a mixed approach, combining protein models with experimental... -
Research Grant, 2016Analysis of Parkin Activity in Pre-clinical Models of Parkinson's
Study Rationale:
Loss-of-function mutations in parkin cause approximately 50% of cases of early-onset Parkinson's disease (PD). Parkin selectively targets impaired mitochondria (powerhouses of the... -
Target Advancement Program, 2016Targeting the LRRK2-PAK6 Pathway in Parkinson's Disease
Study Rationale:
LRRK2 is one of the most attractive therapeutic targets in Parkinson's disease (PD); however, chronic doses of LRRK2 inhibitors result in side effects in pre-clinical models. We... -
Improved Biomarkers and Clinical Outcome Measures, 2016Study of Drug Binding Sites in Alpha-synuclein Fibrils
Objective/Rationale:
This research aims to improve the potential to treat Parkinson's disease (PD) by using active molecules. Various small molecules that produce desired effects have been shown to... -
Biomarkers Across Neurodegenerative Diseases, 2016Cross-disease Brain Image Modeling
Study Rationale:
Individuals with Alzheimer’s and Parkinson’s diseases share typical brain image patterns. The research field has long awaited an intelligent system that could interpret patterns...
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Target Advancement Program, 2016Validation of Cyclin-G Associated kinase (GAK) as a Target for Parkinson's Disease
Study Rationale:
The project will investigate Cyclin-G associated kinase (GAK), a candidate risk gene for Parkinson’s disease (PD), based on genome-wide association studies (GWAS)...
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Our funding programs support basic, translational and clinical research from academia and industry.