The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2022Interaction of Mitochondrial Genes and Lifestyle Factors on Age at Onset in Parkinson’s Disease
Study Rationale: Cellular structures called mitochondria are functionally impaired in Parkinson’s disease (PD). How environmental toxins or lifestyle factors influence mitochondrial function and...
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Outcome Measures, 2022Improving the generalizability and robustness of MRI-derived biomarkers of Parkinson's Disease through analytical and data variability evaluations
Study Rationale: Medical imaging is a promising technique to help with the early diagnosis, understanding, and treatment of Parkinson's disease. Indeed, using advanced image acquisition techniques and...
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Accelerating the Translation of Parkinson's Disease Therapies, 2023Development of Small Molecule Activators of Nurr1 as Potential Therapeutics for Parkinson's Disease
Study Rationale: Parkonson’s disease (PD) is characterized by neuroinflammation and the death of dopamine-producing neurons. Nurr1 is a protein that regulates the activity of genes to reduce...
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Translational Pipeline Program, 2023Targeting Activation of Microglia and Recruitment of Inflammatory Monocytes as a Therapeutic Approach for Parkinson’s Disease
Study Rationale: Inflammation in the brain promotes neurodegeneration and drives the progression of Parkinson’s disease (PD), suggesting that controlling neuroinflammation could provide an important...
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Translational Pipeline Program, 2023Using Sleep Modulation to Enhance the Brain’s Waste Clearance Mechanisms as an Approach to Limiting the Progression of Parkinson’s Disease
Study Rationale: Recent studies have demonstrated that the brains of people with Parkinson’s disease (PD) show a buildup of toxic proteins that is due to an impairment in the brain’s waste clearance...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Assessment of Proinflammatory Cytokines as Biomarkers for Parkinson’s Disease
Study Rationale: We have generated a computer-based model that simulates alterations in molecular mechanisms associated with Parkinson’s disease (PD) genes. This model suggested that, in sporadic...
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Our funding programs support basic, translational and clinical research from academia and industry.