The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2012Validation of ATP13a2 / PARK9 as a Target to Reduce Neurodegeneration Induced by Alpha-Synuclein
Objective/Rationale:
Alpha-synuclein plays a prominent role in Parkinson’s disease and identifying valid targets to ameliorate the neurodegenerative effects of alpha-synuclein is a major therapeutic... -
Clinical Intervention Awards, 2012Phase I Study of AAV2-hAADC Administered by MRI-guided Real-time Convective Infusion
Objective/Rationale:
The purpose of this study is to provide safety data related to enhancements in the clinical delivery procedure for administering Adeno-Associated Virus Encoding Human Aromatic L... -
Repositioning Drugs for PD, 2012Amitriptyline as a Dopamine Neuroprotective Therapy
Objective/Rationale:
The project proposes to repurpose the tricyclic antidepressant medication, amitriptyline (AMI), as a disease-modifying therapy for Parkinson’s disease (PD). AMI is an FDA-approved... -
Neurotrophic Factors Challenge, 2012Validation of IGF-1 as a Neuroprotective Agent in Pre-clinical Models of Parkinson’s DiseaseObjective/Rationale: IGF-1-mediated intracellular signaling pathways engage a wide range of potential survival mechanisms, the PI3K/Akt pathway and the ER stress response in particular, and it has...
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Rapid Response Innovation Awards, 2012Is Parkinson’s Disease a Low-grade Inflammatory Bowel Disease?
Objective/Rationale:
Central and peripheral inflammations are likely to be critical in the initiation and/or development of PD. Data from recent genetic studies suggest a link between PD and gut... -
Repositioning Drugs for PD, 2012Atomoxetine for Cognitive Impairment in Parkinson’s Disease
Objective/Rationale:
Parkinson’s disease (PD) causes well known motor symptoms of tremor, slowness and stiffness, but also leads to cognitive impairment. Research has shown that early loss of cells in...
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Our funding programs support basic, translational and clinical research from academia and industry.