The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2005Engineering Midbrain Dopamine Neurons by Forced Expression of a Novel Dopamine Cell Determinant in Pre-Clinical Model Embryonic Stem Cells
Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Role of Pitx3 in the Development of Midbrain DA Neurons
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is caused by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Molecular...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Studies on Endogenous Neurogenesis in the Adult Mammalian Substantia Nigra
We have published evidence for a slow, endogenous generation of new dopaminergic nerve cells in the adult mouse midbrain, i.e. the nerve cell type lost in Parkinson's disease. (PNAS 100, 7925-7930...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Role of Neural Precursor Cells of Ventricular Wall Origin in Endogenous Plasticity in Animal Models of PD
Stem cells attract much interest in research on neurodegenerative disorders, because it might become possible to replace lost neurons. Because success and feasibility of transplantation approaches are...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Identification of Axon Guidance Molecules Relevant to the Midbrain Dopaminergic System
In Parkinson's patients a substantial number of dopaminergic neurons necessary for proper motor control have died, leading to dyskinesias that make it difficult to walk and talk. A promising approach...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Genetic Screening and Functional Analysis of Factors Regulating Dopaminergic Development and Survival in C. elegans and mammalian systems
Specialized brains cells which produce the chemical signal dopamine degenerate in PD. We believe that genes which control development of these brain cells may be candidates for susceptibility to PD...
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Our funding programs support basic, translational and clinical research from academia and industry.