The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2020Discovery of Selective PET Imaging Agents for Tauopathies and Alpha-Synuclein
Study Rationale:
For reasons not yet understood, a protein called alpha-synuclein clumps in the brain cells of people with Parkinson’s disease. Some evidence suggests that a protein called tau also... -
Biosample Use Program, 2020Metabolomic Analysis of Penetrance, Prognosis and Tracking Biomarkers of LRRK2 PD
Study Rationale:
Mutations in a gene called LRRK2 can cause Parkinson's disease but only a quarter to half of the people who carry one of these mutations will actually develop Parkinson’s in their... -
Therapeutic Pipeline Program, 2020Developing TMEM175 Activators as Therapeutics for Parkinson's Disease
Study Rationale:
Our aim is to develop a drug that will slow or stop the progression of Parkinson’s disease in patients who carry a mutation in the TMEM175 gene. The TMEM175 gene produces a... -
Biosample Use Program, 2020CSF RT-QuIC Alpha-Synuclein Amplification in LRRK2-Parkinson’s Disease
Study Rationale:
Parkinson’s disease caused by genetic mutations in the gene called leucine rich repeat kinase 2 (LRRK2) is clinically indistinguishable from idiopathic Parkinson’s disease, in which... -
Research Grant, 2020Targeting of the Raphe-Cortical Pathway to Reduce Levodopa-Induced Psychosis
Study Rationale:
Parkinson’s disease is best known as a movement disorder, yet non-motor symptoms such as anxiety, depression and psychosis afflict over 50 percent of patients and severely impact... -
Research Grant, 2020More Than Pretty Pictures: Ion Imaging of Lipid Content and Flux Kinetics in Models of Parkinson’s Disease
Study Rationale:
Glycosphingolipids are natural cellular fats. They are components of cellular membranes that fulfill multiple functional roles, from cell structure and transport to signaling. The...
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Our funding programs support basic, translational and clinical research from academia and industry.