The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2022RT-QuIC Testing of Misfolded α-Synuclein in Stage 4 Study; Submandibular Gland Biopsies and CSF Samples
Study Rationale: Normally folded a-synuclein protein is vital to normal brain function. However, misfolded a-synuclein can form the aggregated fibrils that contribute to Parkinson’s disease’s (PD)...
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Expanding Biological Understanding of PD, 2022Identifying Genes that Enhance the Activity of Glucocerebrosidase
Study Rationale: Parkinson’s disease (PD) causes uncontrollable trembling, progressive rigidity of muscles and an inability to walk. We do not yet understand why certain people are more prone than...
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Research Grant, 2022Identifying Novel Target Genes and Compounds for Controlling the Motor Symptoms of Parkinson’s Disease
Study Rationale: Understanding neurological conditions has been among the most difficult challenges in modern medicine. The brain contains more than 86 billion nerve cells that form the neural...
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Magnetic Resonance Imaging Biomarkers, 2022Use of Novel Intestinal Imaging for Early Identification of Parkinson’s Disease and Assessment of Response to Therapies that Reduce Alpha-synuclein Accumulation
Study Rationale: Changes in intestinal contractions are a common feature of early Parkinson’s disease (PD). These changes, which often occur before the onset of movement symptoms, are tied to the...
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Magnetic Resonance Imaging Biomarkers, 2022Dynamic Modeling and Prediction of Parkinsonian Symptom Progression
Study Rationale: Parkinson’s disease (PD) affects different people in different ways. We believe that these differences can offer clues about what happens in the brain before people with PD even begin...
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Research Grant, 2022Development of Irreversible PET Radiotracers for Glucocerebrosidase
Study Rationale: Glucocerebrosidase (GBA) is an enzyme that removes a sugar that is attached to certain fat molecules in the healthy brain. This critical biochemical process begins to malfunction...
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Our funding programs support basic, translational and clinical research from academia and industry.