The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Accelerating Biological Understanding and Therapeutic Translation for PD-Biology
Study Rationale: Mutations in the PINK1 and Parkin genes cause early-onset Parkinson’s disease (PD). In rats with similar mutations in PINK1 and Parkin, we observed pronounced degeneration of nerve...
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Freezing of Gait Program, 2025Treating Freezing of Gait in Parkinson’s Disease Using an ADHD Drug that Reduces Neural Cross-talk: A Multi-center Multi-modal Approach
Study Rationale: Freezing of gait affects four out of five people with Parkinson’s disease (PD), yet this debilitating symptom is not fully treated by any PD medication available. Research has shown...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Assessment of Psilocybin Therapy for Treatment of Depression in Parkinson’s Disease
Study Rationale: Depression is of the most common and disabling symptoms of Parkinson’s disease (PD), and it is linked to poor quality of life and faster disease progression. Unfortunately, we lack...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Investigating the Mechanisms of Alpha-synuclein-induced Anxiety in a Novel Preclinical Model of Parkinson’s Disease
Study Rationale: Although Parkinson’s disease (PD) is known as a movement disorder, non-motor symptoms like anxiety can severely reduce individuals’ quality of life. Unfortunately, we know very little...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025(SUPPLEMENT) Discovery of Translational Biomarkers for Endolysosomal Pathway Pathology Using Lipidomics and Metabolomics
Study Rationale: The endolysosomal system in living cells is comprised of small, specialized structures that contain enzymes that degrade proteins and remove molecular waste. Impaired function of this...
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ASAP CRN Competitive Renewal Opportunity, 2025Examining the Dual Role of Neural Activity in Parkinson’s Disease
Study Rationale: Most previous work on brain circuitry in Parkinson’s disease (PD) has focused on what happens after the loss of dopamine neurons. However, we know that changes in the function of...
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Our funding programs support basic, translational and clinical research from academia and industry.