The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Dyskinesia Challenge, 2014Gene-to-gene Interaction Analysis of Levodopa-induced Dyskinesia
Study Rationale:
Long-term treatment for Parkinson’s with levodopa can cause dyskinesia or involuntary movements. Other drugs like anti-dopaminergics can cause similar abnormal... -
Research Grant, 2014Neuromelanin in Circulating Phagocytes May Reveal Early Neurodegeneration in Parkinson's Disease Supplement
Promising Outcomes of Original Grant:
The pigment neuromelanin is specifically found in the nerves destroyed by Parkinson’s disease. We developed a way to measure neuromelanin and then looked for... -
Research Grant, 2019Pre-formed Fibril-seeded Synucleinopathy: Impact on Proinflammatory Cytokines and Contralateral Excitotoxicity
Promising Outcomes of Original Grant:
We have successfully characterized the time course and magnitude of alpha-synuclein aggregation and neurodegeneration of the nigrostriatal system following... -
Biomarkers of Protein Handling/Autophagy, Exosomes and Lipid, 2019Measuring Lipids in iPSC-derived Dopamine Neurons to Identify Parkinson’s Biomarkers
Study Rationale:
Changes in lipid metabolism have been strongly associated with Parkinson’s disease (PD). Lipids have the potential to be important biomarkers for PD, but the lack of appropriate tools... -
Research Grant, 2019Biologically Meaningful Modulation of Alpha-synuclein Expression via Clenbuterol
Promising Outcomes of Original Grant:
The drug clenbuterol, a beta-2 adrenoreceptor agonist, has been shown to decrease alpha-synuclein expression and to be neuroprotective in some models. Our results... -
Alpha-synculein Biology and Therapies, 2018Effects of Post-translational Modifications on Alpha-synuclein Aggregation
Study Rationale:
Evidence suggests that the protein alpha-synuclein can cause the death of neurons in the brains of people with Parkinson’s disease (PD) by forming clusters (or aggregates) on the...
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Our funding programs support basic, translational and clinical research from academia and industry.