The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2019GBA Sequencing and Detection of Mutations, Deletions, Insertions and Recombinations with the GBA Pseudo Gene
Study Rationale:
Mutations in the GBA gene are the most common genetic cause of Parkinson’s disease. This gene has a nearby pseudogene, which is a genetic material that is very similar to the original... -
Alpha-synculein Biology and Therapies, 2019Chaperones of Alpha-synuclein for Membrane Fusion Involved in Synaptic Transmission
Study Rationale:
Abnormal accumulation of the protein alpha-synuclein is a pathological hallmark of Parkinson’s disease (PD). We and others have evidence that aggregated alpha-synuclein could harm... -
LRRK2 LEAPS, 2018Link between LRRK2, Alpha-synuclein and Lysosomal Function Supplement
Study Rationale:
Our goal is to test whether people with Parkinson’s disease (PD) who carry a LRRK2 mutation (compared to those carrying another genetic PD-predisposing mutation or people with... -
Therapeutic Pipeline Program, 2019Small Molecule Therapeutics Targeting Nurr1
Study Rationale:
Nurr1 is a protein that plays critical roles in the development, maintenance and survival of dopaminergic neurons and, as such, is a potential therapeutic target for treating the... -
Therapeutic Pipeline Program, 2019Development of a Novel TRPML1 Activator for Parkinson’s Disease
Study Rationale:
A primary cause of Parkinson’s disease is build-up of a toxic protein in specific neurons in the brain. There is evidence that in Parkinson’s disease the cellular machinery to clear... -
Epidemiological Parkinson's Risk Modifiers, 2019Association of Dietary Patterns with Parkinson’s Symptoms and Pathology
Study Rationale:
Currently there is no preventive treatment for Parkinson’s disease. Our recent analyses has indicated that healthy dietary patterns such as the MIND (Mediterranean-DASH Intervention...
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Our funding programs support basic, translational and clinical research from academia and industry.