The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2021Brain-penetrating Antisense Oligonucleotide to Down-regulate Alpha-synuclein
Study Rationale:
Antisense oligonucleotides (ASOs) are a new type of therapeutic that have promise for treating Parkinson’s disease. They act by modifying the production of specific proteins, such as... -
, 2020The Role of USP30 in Idiopathic Parkinson’s Disease
Study Rationale:
Dopamine neurons are highly vulnerable to age-dependent increases in mitochondrial dysfunction, oxidative stress, and protein accumulation due to their high metabolic activity... -
Therapeutic Pipeline Program, 2021RNA Targeting Small Molecules as Therapeutics for Parkinson's
Study Rationale:
Abnormal clumping of the protein alpha-synuclein is a hallmark of Parkinson's disease (PD) and a likely cause of neurodegeneration and, ultimately, symptoms. One of the causes... -
Research Grant, 2021Codevelopment of Small-molecule Regulators of Miro1 for the Treatment of Parkinson’s Disease and a GLP Clinical Biomarker Assay
Study Rationale:
The mitochondrial protein Miro1 is elevated in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms. The high level of Miro1 is a pathogenic... -
Therapeutic Pipeline Program, 2021Understand Me for Life: An Intelligibility App for Parkinson's Disease
Study Rationale:
Approximately 90% of people with Parkinson’s develop speech and language problems over the course of the disease, and more than half of these speakers experience problems with... -
Therapeutic Pipeline Program, 2021Dietary Interventions to Slow and Improve Parkinson’s Symptoms by Restructuring the Gut Microbiome and Decreasing Inflammation
Study Rationale:
There is a link between the gut and the brain in Parkinson’s disease (PD), and gut bacteria may play an important role. Gut bacteria they affect the bowel mucus barrier, produce...
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Our funding programs support basic, translational and clinical research from academia and industry.