The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Inflammatory Phenotypes in Differentiated Human LRRK2 and GBA Mutation IPS Cell Lines
Promising Outcomes of Original Grant:
With previous funding from MJFF, we determined how the activity of LRRK2 genetic mutations contributed to inflammation in Parkinson's. We found that inflammation... -
Research Grant, 2018Assess p935 LRRK2 and Total LRRK2 Levels Using an MSD Assay in Whole Blood
Study Rationale:
Some variants in the LRRK2 gene have been linked to increased risk of Parkinson's disease. This has made LRRK2 a promising target for Parkinson's drug development. To increase our... -
Research Grant, 2018Autologous Long-Term Cell Restorative Therapy for Parkinson's Disease
Study Rationale:
Cell replacement using induced pluripotent stem cells (iPSCs) is a potential restorative therapy for Parkinson's disease. Replacing brain cells that produce dopamine, a chemical... -
Research Grant, 2018Clinicopathological Correlates in LRRK2-Related Parkinson's Disease
Promising Outcomes of Original Grant:
With previous funding from MJFF, we established the largest collection of clinically characterized autopsies from Parkinson's patients with a LRRK2 mutation, from... -
Research Grant, 2018Alpha-synuclein/Tau Imaging Consortium
Study Rationale:
Abnormal forms of alpha-synuclein and tau proteins are hallmarks of Parkinson's disease and frontotemporal dementia (FTD), respectively, and believed to be early disease indicators... -
Research Grant, 2018Exploring the Mechanisms of Neuropathology in D620N VPS35 Knockin Mice
Study Rationale:
Recent findings indicate that mutations in the VPS35 gene cause a type of familial Parkinson's disease. Normally VPS35 is involved in the trafficking of protein cargo, but we don't...
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Our funding programs support basic, translational and clinical research from academia and industry.