The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Autophagy and Mitochondrial Dysfunction as Potential Therapeutic Targets in Inherited Parkinson's Disease
Study Rationale:
Mutations (changes) in the gene that controls the production of enzyme glucocerebrosidase (GCase) are the most common risk factor for inherited Parkinson's disease (PD). We have... -
Research Grant, 2018Assessing Proteins LRRK2, GCase and Cytokines in Immune Cells
Study Rationale:
Leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are two proteins linked to an increased risk of developing Parkinson’s disease (PD). Both proteins are produced by... -
Research Grant, 2018Studying GBA Pseudogene as a Controller of GBA and Alpha-synuclein
Study Rationale:
Mutations (changes) in the GBA gene are the most common genetic risk factor for Parkinson’s disease (PD). GBA has a clone called pseudogene, a similar stretch of DNA that, unlike the... -
GBA Biology and Therapies, 2018Link between LRRK2 Activity and Glucocerebrosidase Deficits in Idiopathic Parkinson’s Disease
Study Rationale:
Earlier work from this group reported greater LRRK2 activity in people with idiopathic (cause unknown) Parkinson’s. This project builds on those findings to investigate how that... -
GBA Biology and Therapies, 2018Analyzing Genetic Modifiers Using a CRISPR Activation/Inhibition GBA-PD Model
Study Rationale:
Clinical and genetic studies show that mutations in the GBA gene are risk factors for developing Parkinson’s disease (PD) and lead to an accumulation of glycolipids in the lysosome... -
GBA Biology and Therapies, 2018Targeting GCase with Novel Pharmacological Chaperones
Study Rationale:
People who have mutations in the GBA gene have a higher chance of developing Parkinson's disease (PD). The GBA gene encodes the glucerebrosidase (GCase) protein, an enzyme located...
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Our funding programs support basic, translational and clinical research from academia and industry.