The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018URMC-099 in an In Vivo AAV-hSYN Model of Parkinson’s Disease
Study Rationale:
Parkinson's disease (PD) can be modeled by over-expressing human synuclein, a protein that can clump together to disrupt normal signaling in dopamine-containing neurons, which in turn... -
Research Grant, 2018LRRK2-Mediated Rab Protein Phosphorylation in Monocytes and Neutrophils in Parkinson's Disease
Study Rationale:
Mutations in the LRRK2 gene cause some forms of Parkinson's disease. Studying this gene's effects has provided insight into the physiological processes that lead to genetic and... -
Research Grant, 2018Feasibility of Screening for Parkinson's Genetic Risk Factors in People of Asian Ancestry
Study Rationale:
Mutations in the LRRK2 gene can cause Parkinson's disease (PD), and therapies against associated dysfunction in the LRRK2 protein are in clinical trials. A specific variant of the... -
Research Grant, 2018Analysis of the LRRK2-Rab Signaling Pathway
Promising Outcomes of Original Grant:
The highlight of our teams' recent MJFF funded research has been the discovery of the key physiological targets of LRRK2 that comprise a group of proteins termed... -
Research Grant, 2018Analyzing Parkinson’s Data with the Razor Platform for Hypothesis Generation and Scientific Decision-making
Study Rationale:
Experts from various biomedical fields are trying to identify treatment options for Parkinson's disease, but approaches that target a single gene or mechanism have thus far been... -
Research Grant, 2016Chemical Knockdown of LRRK2 by Small Molecule PROTACS
Study Rationale:
LRRK2 is a protein kinase that appears to be a key driver of some forms of Parkinson's disease (PD). Several potent, selective, brain-penetrant LRRK2 kinase inhibitors have been...
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Our funding programs support basic, translational and clinical research from academia and industry.