The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Cohort Consortium Resource Request, 2013Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene
Objective/Rationale:
Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease
Study Rationale:
We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This... -
Target Validation, 2011Preferential Targeting of Subpopulations of 5-HT1A Receptors
Objective/Rationale:
Although Parkinson's disease (PD) is primarily caused by dopamine dysfunction, function of serotonin (another neurotransmitter) is also affected. This suggests that serotonergic... -
Rapid Response Innovation Awards, 2011Informing Clinical Decision Making in the Pre-motor Period of Parkinson Disease
Objective/Rationale:
Currently, the diagnosis of Parkinson disease (PD) relies on recognition of impaired movement, which occurs decades after neurodegeneration begins. By looking at changes in sleep... -
Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Targeting a Phospholipid Unique to Mitochondrial Membranes as a Therapeutic for Parkinson’s Disease
Study Rationale: Mitochondria are energy-generating structures vital to the health of all cells. In Parkinson’s disease (PD), mitochondrial dysfunction leads to neuronal degeneration and to the motor...
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LRRK2, 2011fMRI of First Degree Relatives of LRRK2 Positive Parkinson's Disease Patients
Objective/Rationale:
First, to study the effect of the presence of the LRRK2 G2019S mutation on brain activation patterns in PD patients who recently converted into a diseased state by comparing...
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