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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2014
    Targeting the Stress Sensor PERK for the Treatment of Parkinson´s Disease

    Objective/Rationale:             
    Parkinson's disease (PD) is characterized by impairment of motor control as a result from extensive neuron death. The primary mechanism responsible for the progressive...

  • Improved Neuromodulation Approaches, 2014
    Optogenetic Restoration of Basal Ganglia Function to Treat Parkinson’s Disease

    Study Rationale:                   
    Optogenetics has gained wide interest as a tool to understand the function of circuits influencing brain diseases. This approach uses proteins that respond to...

  • Improved Neuromodulation Approaches, 2014
    Machine Learning for Programming Deep Brain Stimulation Arrays

    Study Rationale:                   
    Deep brain stimulation (DBS) implants for treating Parkinson’s disease currently consist of four round electrodes stacked along a thin cylindrical carrier lead. When...

  • Improved Neuromodulation Approaches, 2014
    Multicenter Clinical Trial of Deep Brain Stimulation in Early Stage Parkinson’s Disease

    Study Rationale:
    Deep brain stimulation (DBS) is an effective treatment for many patients with advanced stage Parkinson’s disease (PD) when symptoms are not adequately controlled with medication...

  • Improved Neuromodulation Approaches, 2014
    Chronic Directional Deep Brain Stimulation in Parkinson’s Disease

    Study Rationale:       
    The side effects of deep brain stimulation (DBS) in Parkinson’s disease are related to overstimulation of the brain target structure and neighboring regions. This clinical study...

  • Research Grant, 2014
    Phase IIb Study of Intranasal Glutathione in Parkinson's Disease

    Study Rationale:
    The loss of glutathione in the brain of individuals with PD occurs years before the onset of motor symptoms. Glutathione has been proposed as neuroprotective therapy in PD for decades...

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