The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LEAPS, 2005Development and Optimization of a Regulatable Gene Switch for Gene Therapies of Parkinson’s Disease
Gene therapy holds tremendous potential for the treatment of Parkinson's disease. By using a virus or other DNA delivery system to permanently insert a new gene into critical regions of a Parkinson...
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Dopamine-Non-Responsive Symptoms of Parkinson's Disease, 2006The ReStore Study
Apathy is a syndrome characterized by a primary lack of motivation and is manifested as a lack of effort and productivity, dependence on others for structuring daily activities, loss of interest in...
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Dopamine-Non-Responsive Symptoms of Parkinson's Disease, 2006Development of a Model of Postural Disturbance by Lesioning Non-cholinergic Neurons
Mounting evidence suggests that a small structure at the bottom of the brain called pedunculopontine nucleus is involved in the development of gait failure and postural instability in PD. We propose...
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Dopamine-Non-Responsive Symptoms of Parkinson's Disease, 2006Evaluation of gastrointestinal motility in parkinsonian rodents
Gastrointestinal (GI) symptoms, such as nausea, bloating, and constipation occur in nearly every patient afflicted with Parkinson's Disease (PD) at some point in their illness. These symptoms on their...
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Target Validation, 2007Validation of Sirtuin 2 Deacetylase as a Therapeutic Target in Parkinson’s disease
Objective/Rationale:
A major known risk factor in Parkinson’s disease is the misfolding, aggregation and abnormal accumulation of the protein alpha-synuclein. The goal of the proposed work is to... -
Rapid Response Innovation Awards, 2007Understanding the Role of Glucocerebrosidase in Parkinson's Disease Pathogenesis: Toward a New Genetic Model of Sporadic PD
Gaucher’s disease is a glycosphingolipid-storage disease in which homozygous mutations are found in the lysosomal enzyme glucocerebrosidase (GBA) gene. PD and Gaucher’s disease share many clinical and...
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