The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2012Development of Nurr1-RXR Heterodimer Selective Agonists for Parkinson's Disease
Promising Outcomes of Original Grant:
We hypothesized that Nurr1 could be targeted indirectly with small molecules through other nuclear hormone receptors, and that such compounds would have... -
Rapid Response Innovation Awards, 2012Attenuation of Neuroinflammation by Brain-targeted Liposomal Methylprednisolone (2B3-201) in Two Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
Based on increasing evidence of a chronic, self-sustaining environment of inflammation in the brain – or neuroinflammation – in Parkinson’s disease (PD), the objective of the... -
Rapid Response Innovation Awards, 2012A Small Molecule Approach to Correct Striatal Cholinergic Interneuron Dysfunction
Objective/Rationale:
There is growing evidence that cholinergic interneurons (ChIs) in the striatum undergo maladaptive biochemical changes leading to their hyperactivation under conditions of... -
LRRK2 Biology LEAPS, 2012Protein Interaction Network Analysis and Pathway Modeling for LRRK2
Objective/Rationale:
Mutations in the Leucine-rich Repeat Kinase 2 gene (LRRK2) are the single most common cause for inherited Parkinson's disease (PD). LRRK2 is a large protein consisting of... -
MJFF Research Grant, 2012Neuroimaging Markers Predict Cognitive Decline in PD
Promising Outcomes of Original Grant:
Excessive amounts of amyloid in brain tissue are believed to be toxic and cause the neuronal damage that results in dementia. Amyloid deposits can be detected in... -
MJFF Research Grant, 2012Mechanisms of Parkin Recruitment and Mitophagy
Promising Outcomes of Original Grant:
The protein Parkin is thought to be required for the maintenance of healthy mitochondria, critical subcellular organelles that govern cellular energy production...
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Our funding programs support basic, translational and clinical research from academia and industry.