The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Pharmacodynamic Assays, 2013Fluorescence Fluctuation Spectroscopy Assays to Monitor the Activity of LRRK2
Objective/Rationale:
LRRK2 is a major protein target for therapeutic treatment of Parkinson’s disease (PD). The lack of assays (experiment set-ups) available for measuring the activity of... -
Rapid Response Innovation Awards, 2014Integrative Genomic Approach to Discover Disease Mechanisms Underlying Parkinson’s Disease
Objective/Rationale:
Complex diseases such as Parkinson’s are caused by a combination of genetic, environmental and lifestyle factors that all lead to different causal regulation... -
Research Grant, 2014Tumorigenesis in Parkinson’s Disease
Objective/Rationale:
The aim of the study is to investigate whether disease-causing genetic mutations in Parkinson’s disease (PD), particularly in the LRRK2 gene, also predispose... -
Target Validation, 2014Targeted Disruption of TRIM28 to Reduce Alpha-synuclein Levels
Objective/Rationale:
We have previously performed a screen to find new pathways that may regulate alpha-synuclein, the toxic protein that accumulates in the cells of people with Parkinson’s disease (PD... -
Target Validation, 2014Validating BAG5 as a Therapeutic Target of Parkinson’s Disease
Objective/Rationale:
Poor handling and elimination of misfolded proteins has been identified as central in the development of Parkinson’s disease (PD). A special class of proteins within the cell... -
Rapid Response Innovation Awards, 2014Intrabodies in Pre-clinical Models of Parkinson’s Disease
Objective/Rationale:
Progressive loss of dopamine neurons and clumps of the protein alpha-synuclein are hallmarks of Parkinson’s disease (PD). Intrabodies are small antibody fragments that target...
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Our funding programs support basic, translational and clinical research from academia and industry.