The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2014Cofilin-1 as a Major Contributor to Oxidative Stress-mediated Cell Death in Parkinson’s Disease
Objective/Rationale:
Oxidative stress, a process that stops the cell producing energy efficiently, is a key cause of the death of neurons in Parkinson’s disease. We have previously shown that oxidative... -
LRRK2 Cohort Consortium Resource Request, 2013Analysis and Replication of a Genetic Interaction between LRRK2 and PARK16
Study Rationale:
We previously showed that variants in two known Parkinson’s disease (PD) genes, LRRK2 and PARK16, genetically interact to increase risk of disease. Learning more about genetic variants... -
LRRK2 Cohort Consortium Resource Request, 2013Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene
Objective/Rationale:
Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called... -
LRRK2 Cohort Consortium Resource Request, 2013Influence of Immune Subtypes on the LRRK2 Phenotype
Study Rationale:
There is growing evidence for a relevant influence of chronic and subtle inflammation on Parkinson’s disease (PD). The most common causes of monogenic (involving one gene) PD are... -
Therapeutic Pipeline Program, 2014Characterization of a Novel Therapy To Selectively Silence Alpha-Synuclein In Monoaminergic Neurons
Objective/Rationale:
The biotech company nLife Therapeutics has designed a molecule (NLF-PD-1233) to target specific neurons in the brain to reduce expression of the protein alpha-synuclein (which... -
Rapid Response Innovation Awards, 2014Electromyography Signals as Biomarkers for Parkinson’s Disease
Objective/Rationale:
A simple, painless and reliable method to detect Parkinson’s disease at an early stage is very important to patients, doctors and researchers. Doctors want to help patients early...
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Our funding programs support basic, translational and clinical research from academia and industry.