The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2015Targeting the NLRP3 Inflammasome in Models of Parkinson's Disease
Objective/Rationale:
Chronic inflammation within the brain is emerging as a possible driver in the progression of Parkinson’s disease (PD). Inflammasomes are protein complexes that... -
Therapeutic Pipeline Program, 2014Optimization of Dopamine D4 Antagonists for the Treatment of Levodopa-induced Dyskinesia
Study Rationale:
Levodopa-induced dyskinesia is a major dose-limiting effect associated with long-term treatment of Parkinson’s disease (PD). There are no effective treatments for... -
Biomarkers Across Neurodegenerative Diseases, 2014Subcortical Shape Analysis for Joint Biomarker Discovery
Study Rationale:
We know that both Alzheimer’s and Parkinson’s diseases affect certain parts of the brain first, before affecting the rest of the brain, and often before people start... -
Research Grant, 2014Retinal Pathology in Parkinson’s Disease: Implications for Vision and Biomarkers
Study Rationale:
Vision problems are not what most of us think of when we think of Parkinson’s disease (PD), but there are some physical changes in the retina of people with PD... -
Research Grant, 2014Development of a Biomarker Assay for Oxidized DJ-1 in Parkinson’s Disease
Study Rationale:
Mutations in the DJ-1 gene cause an early-onset form of Parkinson’s disease (PD). The DJ-1 protein is an attractive biomarker for sporadic PD, as well, since it is... -
Research Grant, 2014Role of Phosphodiesterase 10A in Early Sporadic Parkinson’s Disease
Study Rationale:
We have collected preliminary data from people who were recently diagnosed with Parkinson's disease (PD), which show that an enzyme called phosphodiesterase 10A (PDE...
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Our funding programs support basic, translational and clinical research from academia and industry.