The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2010Viral Over-expression of Alpha Synuclein
Promising Outcomes of Original Grant:
In our previous grant, we attempted to create a bilateral model of PD using viral over expression of alpha-synuclein. The performance of the study was near... -
MJFF Research Grant, 2010A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients
Promising Outcomes of Original Grant:
In keeping with our original hypothesis, we determined the following: 1) Being in a parkinsonian state (i.e., following 6-OHDA-induced lesions) alters impulsivity... -
Improving Delivery of Parkinson's Disease Therapeutics to th, 2010Novel Antibodies for the Delivery of Parkinson's Therapeutics
Promising Outcomes of Original Grant:
The initial granting period resulted in the successful identification of antibodies capable of targeting and internalizing into novel in vitro blood-brain barrier... -
Target Validation, 2010Validation of VPS41, a Protein Involved in Lysosomal Trafficking, as a Target for Parkinson Disease Therapy
Promising Outcomes of Original Grant:
VPS41 was identified in a C. elegans system. In the original funded grant, we demonstrated that human VPS41 (hVPS41) was also protective in C. elegans, performed a... -
Rapid Response Innovation Awards, 2010Development of In-vivo Models of Prion-like Transfer of Alpha-synuclein
Promising Outcomes of Original Grant:
We aimed at assessing the prion-like hypothesis of alpha-synuclein spread. Prions are small proteins that can move between cells, acting as infectious agents... -
MJFF Research Grant, 2010In-vivo SPECT Imaging of Synuclein Aggregation with Morphology Specific Antibody Based Ligands
Promising Outcomes of Original Grant:
The protein alpha-synuclein (a-syn) has been strongly correlated with PD, and small a-syn aggregates are very toxic and may be an early indicator of the disease...
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Our funding programs support basic, translational and clinical research from academia and industry.