The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2019CRISPRi/dCas9 Downregulation of Alpha-synuclein as a Novel Gene Therapy
Study Rationale:
Neurodegeneration in the brains of people with Parkinson’s may be caused by protein clumps called Lewy bodies, the pathological hallmark of the disease. Lewy bodies consist of a... -
Research Grant, 2019The Synaptic Vesicle Cycle in Parkinson’s Disease
Study Rationale:
Many of the proteins implicated in Parkinson’s disease appear to have a role at the nerve terminal, presumably in neurotransmitter release. However, the function of most has remained... -
Therapeutic Pipeline Program, 2019Mapping Brain Response Patterns to Deep Brain Stimulation with FMRI
Study Rationale:
Deep brain stimulation (DBS) targets malfunctioning brain circuits. Commonly used to treat Parkinson’s disease (PD), this surgical therapy can produce striking clinical benefits when... -
Research Grant, 2019Targeting LRRK2 in Models of Gastrointestinal Inflammation
Study Rationale:
We seek to investigate the extent to which gut inflammation triggers brain inflammation and Parkinson’s-like pathology and the role of LRRK2 and Tumor Necrosis Factor (TNF)-dependent... -
Research Grant, 2019Alpha-Synuclein PET Imaging Tracer Development
Study Rationale:
Alpha-synuclein is a protein that aggregates in several brain diseases, including Parkinson’s, dementia with Lewy bodies and multiple system atrophy. There is no established method... -
Target Advancement Program, 2019Analysis and Amplification of Pathological Alpha-synuclein from Brain Tissue
Study Rationale:
Parkinson’s disease is characterized by the misfolding and accumulation of the alpha-synuclein protein in the brain. Therefore, alpha-synuclein-based disease...
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Our funding programs support basic, translational and clinical research from academia and industry.