The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Novel Approaches to Drug Discovery for Parkinson's Disease, 2007Development of MX-4565, a Novel Estrogen Analogue, for the Treatment of Parkinson's Disease
Objective/Rationale:
MX-4565 is a compound that is highly potent in protecting nerve cells from death in a number of cell culture and animal models systems. For example, it has been shown to provide... -
Novel Approaches to Drug Discovery for Parkinson's Disease, 2007Fisetin and Derivatives as Neuroprotective Drugs for the Treatment of Parkinson's Disease
Objective/Rationale:
Glutathione (GSH) is an antioxidant produced naturally by cells thereby providing them with a defense against oxidative stress. There is good evidence that GSH levels decrease in... -
Novel Approaches to Drug Discovery for Parkinson's Disease, 2007Targeting the PTEN/mTOR/Autophagy Pathway
Objective/Rationale:
A major hurdle in the development of drugs for Parkinson's disease (PD) is the lack of accurate animal models for the disease. We describe new animal models that harbor defects... -
Rapid Response Innovation Awards, 2007Development of a Cellular System to Screen for Small Molecules that Upregulate the hVMAT2 Promoter Activity
Objective/Rationale:
We will develop an essential cellular system as a platform for future high throughput screen (HTS) for novel small molecules that increase levels of the human vesicular monoamine... -
Rapid Response Innovation Awards, 2007Development and Initial Characterization of an Enzyme-linked Immunosorbent Assay for the Candidate PD Risk Marker ST13
Objective/Rationale:
Clinical signs of Parkinson’s disease develop only after the death of around 70 percent of vulnerable dopaminergic neurons. Laboratory tests for PD are not currently available... -
Rapid Response Innovation Awards, 2007Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
Objective/Rationale:
The objective of this study is to explore the effects of methylphenidate on the gait of patients with Parkinson’s disease who are experiencing shuffling and freezing...
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