The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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iPSC Phenotyping Environmental Exposure Program, 2024Using Stem-cell Derived Brain-chip Technologies to Evaluate the Contributions of Environmental Toxins to Parkinson’s Disease
Study Rationale: Chronic exposure to environmental contaminants is believed to play an important role in the initiation of Parkinson’s disease (PD). With an estimated 40,000 to 60,000 chemicals that...
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iPSC Phenotyping Environmental Exposure Program, 2024Use of a Stem-cell-based Platform to Screen for Environmental Factors in Parkinson’s Disease
Study Rationale: Both environmental and genetic factors are believed to be involved in Parkinson’s disease (PD). Although the genetic mutations linked to PD have been studied intensively, it is...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Characterization of a Preclinical Model Bearing a Parkinson’s Disease–linked Mutation in PLA2G6
Study Rationale: Mutations in the PLA2G6 gene lead to neurodegeneration linked to Parkinson’s disease (PD), but the mechanism is unknown. The gene encodes an enzyme that breaks down the lipid...
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Spring 2022 RFA: Therapeutic Pipeline Program Pre-Clinical, 2024(SUPPLEMENT) Targeting Phosphoinositides for Parkinson’s Disease Therapy
Study Rationale: Phosphoinositides (PIPs) are a group of lipids that build cell membranes and play critical roles in mechanisms that control cell’s growth, movement, propagation and death. Recent...
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Spring 2022 RFA: Therapeutic Pipeline Program Pre-Clinical, 2024Exploring Paxalisib as a Novel Therapeutic for Parkinson’s Disease
Study Rationale: Studies in preclinical models of Parkinson’s disease (PD) and in postmortem PD brains suggest that a signaling pathway that is switched on by activation of a protein called...
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, 2024Epigenetic Analysis of Peripheral Immunity in Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) has increasingly been linked to dysfunction in the immune system, with evidence showing abnormal activity in blood immune cells and their potential role in...
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Our funding programs support basic, translational and clinical research from academia and industry.