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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2012
    Phase I-B Clinical Trial of AVE8112 for Cognitive Impairment in Parkinson’s Disease

    Objective/Rationale:
    Cognitive impairment is a symptom seen in Parkinson’s disease (PD) patients, and some can progress to dementia. AVE8112 is a PDE4 inhibitor that was in development by the...

  • Cognition Biomarkers, 2013
    Identification and Validation of Cerebrospinal Fluid Markers Related to Altered Amyloid-beta Processing in the Prediction of Dementia Associated with Parkinson’s Disease

    Objective/Rationale:             
    Patients with Parkinson’s disease (PD) are at increased risk to develop dementia compared with the general population. However, not all patients experience this...

  • Research Grant, 2013
    Validation of the Movement Disorders Society Criteria for Mild Cognitive Impairment in Parkinson’s Disease

    Objective/Rationale:          
    Dementia in Parkinson’s disease (PD) is a serious health issue and a major concern for many PD patients. Mild cognitive impairment (MCI) is considered a transitional...

  • MJFF Research Grant, 2012
    Neuroimaging Markers Predict Cognitive Decline in PD

    Promising Outcomes of Original Grant:
    Excessive amounts of amyloid in brain tissue are believed to be toxic and cause the neuronal damage that results in dementia.  Amyloid deposits can be detected in...

  • Improved Biomarkers and Clinical Outcome Measures, 2015
    Validation of a Performance-based Assessment of Functional Ability Related to Cognition in Parkinson’s Disease

    Study Rationale:                   
    There is a pressing need for new treatments to address cognitive impairment in Parkinson’s disease, yet there is no consensus on how to best evaluate their...

  • Diversity, Equity and Inclusivity in Parkinson's research, 2021
    Study of Cognitive Differences in a South Asian Population with Parkinson’s Disease

    Study Rationale: Research on Parkinson’s disease (PD) has focused mainly on White, affluent populations. Little is known about PD in people of color. East London is one of the most diverse parts of...

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