The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improving Delivery of Parkinson's Disease Therapeutics, 2008Utilizing Novel Tracers to Determine the Distribution of Therapeutic Agents In Vivo
Objective/Rationale:
This project will study the delivery and distribution of promising therapeutics for Parkinson’s disease. The explored compounds will be infused directly into the brain of npre... -
Improving Delivery of Parkinson's Disease Therapeutics to th, 2008Intranasal Delivery of GDNF for Parkinson's Disease: Next Steps
Objective/Rationale:
GDNF, a naturally-occurring growth factor capable of protecting and promoting the survival of dopamine neurons, has great potential as a treatment for Parkinson’s disease. However... -
MJFF Research Grant, 2008DNA Nanoparticle Therapy for Parkinson’s Disease
Promising Outcomes of Original Grant:
Recombinant plasmid DNA encoding for glial cell line-derived neurotrophic factor (GDNF) was compacted into nanoparticles, injected safely into the brain, and... -
Rapid Response Innovation Awards, 2009Crystal Structure of Alpha-Synuclein; Toward Rational Drug Design
Objective/Rationale: The alpha-synuclein is implicated in the pathogenesis of Parkinson’s disease. An aggregated form of synuclein containing many molecules has been proposed to interact destructively...
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Rapid Response Innovation Awards, 2009Probing the Neuroprotective Effects of Haploinsufficiency of RanBP2 in Neurotoxicant-induced Experimental Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
A partial deficit in the level of Ran-binding protein-2 (RanBP2) confers neuroprotection to neurons upon aging and deleterious stimuli promoting oxidative stress, a stress... -
Rapid Response Innovation Awards, 2009Identification of Substrates and Development of a Cell Based Assay for LRRK2
Objective/Rationale:
Inherited mutations in a gene called LRRK2 have recently been discovered to cause Parkinson’s disease. The LRRK2 gene encodes an enzyme called a kinase, which is more active when...
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Our funding programs support basic, translational and clinical research from academia and industry.