The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Aligning Science Across Parkinson's, 2021Cortical Pathophysiology of Parkinsonism
Study Rationale:
The outer mantle of the brain, the cerebral cortex, plays a significant role in selecting and controlling movements. Changes in the activity of cortical neurons are key to disorders... -
Research Grant, 2021Development of Alpha-synuclein and Tau Imaging Agents
Study Rationale: Accumulation of alpha-synuclein and tau protein aggregates are pathological hallmarks of Parkinson’s disease (PD) and Frontal Temporal Dementia (FTD), respectively. The appearance of...
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Outcome Measures, 2021Development of a Method for Assessing the Effectiveness of Alpha-synuclein Immunotherapy
Study Rationale: Parkinson’s disease (PD) is characterized by the buildup of misfolded forms of alpha-synuclein. A vaccine designed to target this abnormal protein has demonstrated safety...
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Therapeutic Pipeline Program, 2021Development of an Anti-inflammatory Drug for the Treatment of Parkinson’s Disease
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the degeneration of neurons in Parkinson’s disease (PD)...
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Research Grant, 2021Preclinical Testing of a Novel Tracer for Imaging Alpha-synuclein Aggregates
Study Rationale: In Parkinson's disease (PD), the protein alpha-synuclein is structurally altered such that clumps of alpha-synuclein accumulate in the brain. These aggregates impair the function of...
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Target Advancement Program, 2021Enhancing Treatment Efficacy by Eliminating L-dopa Metabolizing Gut Bacteria
Study Rationale: Levodopa (L-dopa) is the primary medication used to treat Parkinson’s disease (PD). For L-dopa to exert its effect, it must enter the brain and be converted to the chemical dopamine...
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Our funding programs support basic, translational and clinical research from academia and industry.