The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2009Development of Potent Conformation-Specific Compounds Directed to Monomeric Alpha-Synuclein
Promising Outcomes of Original Grant:
The goal of our original funded grant was to use our alpha-synuclein assay to identify compounds that prevent conformational change to the fully open form of the... -
Improving Delivery of Parkinson's Disease Therapeutics to th, 2010Novel Antibodies for the Delivery of Parkinson's Therapeutics
Promising Outcomes of Original Grant:
The initial granting period resulted in the successful identification of antibodies capable of targeting and internalizing into novel in vitro blood-brain barrier... -
Rapid Response Innovation Awards, 2009Evaluation of a Viral Non-coding RNA as a Neuroprotective and Neurorestorative Therapy in Chronic Models of Parkinson's Disease
Promising Outcomes of Original Grant:
Previously, we asked whether a novel viral non-coding RNA (an RNA which does not appear to encode a protein), but with known pro-life functions, could act to... -
Target Validation, 2010Validation of VPS41, a Protein Involved in Lysosomal Trafficking, as a Target for Parkinson Disease Therapy
Promising Outcomes of Original Grant:
VPS41 was identified in a C. elegans system. In the original funded grant, we demonstrated that human VPS41 (hVPS41) was also protective in C. elegans, performed a... -
MJFF Research Grant, 2009N-Acetylcysteine CSF Levels and Biomarkers in a Pre-clinical Model of PD
Objective/Rationale:
N-Acetylcysteine (NAC) is an orally absorbed compound that supports neuronal synthesis of glutathione, a key neuronal antioxidant. Our objective here is to establish the blood and... -
MJFF Research Grant, 2010Promoting Widespread Data Sharing Among Scientists
Objective/Rationale:
When scientists carry out experiments and observations, they typically have very specific questions. It is frequently the case that data collection is relevant to issues and...
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Our funding programs support basic, translational and clinical research from academia and industry.