The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2019Managing Levodopa-induced Dyskinesias by Targeting Dopamine D1 Receptor Signaling
Study Rationale:
Parkinson’s is a complex brain disease caused by the gradual loss of brain cells producing the neurotransmitter dopamine, which controls movement, emotion and affect. However... -
Access to Data and Biospecimens, 2019Convergence of LRRK2 and GBA in the Pathogenesis of Parkinson’s Disease Supplement
Promising Outcomes of Original Grant:
In our original project we used dopamine cells derived from induced pluripotent stem cells (iPSCs) from people with Parkinson’s-associated LRRK2 or GBA mutations... -
Therapeutic Pipeline Program, 2019Small Molecule Therapeutics Targeting Nurr1
Study Rationale:
Nurr1 is a protein that plays critical roles in the development, maintenance and survival of dopaminergic neurons and, as such, is a potential therapeutic target for treating the... -
Target Advancement Program, 2019Investigating Vulnerability of Subsets of Dopaminergic Neurons
Study Rationale:
Brain cells that produce the neurotransmitter dopamine are the most vulnerable to cell death in Parkinson’s disease (PD), but the reasons for this are not known. New techniques have... -
Research Grant, 2019Inhibition of LRRK2 Roc-COR GTPase
Study Rationale:
The LRRK2 protein is overactive in people with Parkinson’s and a mutation in the LRRK2 gene. Recent research shows LRRK2 may be overactive in a sporadic (cause unknown) Parkinson’s... -
Therapeutic Pipeline Program, 2019Development of a Novel TRPML1 Activator for Parkinson’s Disease
Study Rationale:
A primary cause of Parkinson’s disease is build-up of a toxic protein in specific neurons in the brain. There is evidence that in Parkinson’s disease the cellular machinery to clear...
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Our funding programs support basic, translational and clinical research from academia and industry.