To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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ROSA SNCA Knockout Mouse*
Mouse Model
Mice carrying SNCA knockout allele and Gt(ROSA)26Sor Cre reporter allele. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028560
LRRK2 S910A/S935A Knockin Mouse*
Mouse Model
Mice carrying LRRK2 S910A and S935A mutations in exon 21. Model was generated and deposited by Dario Alessi at University of Dundee through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028801
ROSA LRRK2 R1441C Mouse*
Mouse Model
Transgenic mice with human LRRK2 R1441C inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery).
SNCAbow Mouse*
Mouse Model
Mouse expressing either nuclear localized SNCAWT:TagBFP, SNCAA30P:mTFP1, or SNCAA53T:mKO2 in cre-expressing tissues of the offspring directed by CAG promoter followed by three pairs of orthogonal lox sites (LoxN, Lox2272, and LoxP), and the SNCAbow construct; all targeted into the Gt(ROSA)26Sor locus. Each α-synuclein sequence contains a C-terminal epitope tag: SNCAWT tagged with V5, SNCAA30P tagged with 3XHA, or SNCAA53T tagged with Myc. Model was generated and deposited by Rodger Liddle at Duke University Medical Center through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:037603
Rab 8A Antibody
Antibody
Mouse anti-Rab8A antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJF-R22-79-3). The new chimeric antibody is approved for immunoblotting, immunoprecipitation, immunostaining, and flow cytometry and can be detected using Fc-specific secondary antibodies to mouse IgG.
ASAH1 Knockout A549 Cell Line
Immortalized Cell
A549 cell with homozygous knockout of ASAH1.
Estimated Availability: Early 2025
Human GCase Antibody
Antibody
Rabbit monoclonal antibody directed against human GCase for immunostaining applications. Antibody generation failed.
MCU Floxed DAT-Cre Mouse*
Mouse Model
MCU Floxed DAT-Cre mice were generated by crossing floxed exons 5 and 6 of the MCU gene (Zampese et al. 2022) with mice expressing Cre recombinase under the dopaminergic-specific DAT to induce knock-out of MCU (mitochondrial Ca2+ uniporter), resulting in the loss of MCU specifically in dopaminergic cells. Model was designed by D. James Surmeier at Northwestern University and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038988
MCI-PARK Mouse*
Mouse Model
Homozygous knockout mice targeting Ndufs2 (NADH:ubquinone oxidoreductase core subunit S2) specifically in dopaminergic neurons. Mice with floxed Ndufs2 allele were crossed with mice expressing Cre recombinase under the control of Slc6ac (dopamine transporter; DAT) promoter. Model was generated and deposited by D. James Surmeier at Northwestern University through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036313
iNDI-PD iPSCs
Human iPS Cell
iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) lines are available at JAX. These lines were developed in partnership with NIH, Chan Zuckerberg Initiative, and Aligning Science Across Parkinson's (ASAP) to include iPSC lines expressing PD-associated mutations in SCNA, LRRK2, GBA, PINK1 and PRKN as well as mutation-corrected isogenic revertant controls. An inventory of available lines can be found here: https://www.jax.org/jax-mice-and-services/ipsc/cells-collection
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic