To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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GBA D409V Knockin x Thy1-Alpha-Synuclein Mouse
Mouse Model
Transgenic mice resulting from the cross between transgenic mice overexpressing the D409V mutant form of GBA (homozygous) and transgenic mice overexpressing wild type human alpha-synuclein directed by the murine Thy-1 promoter (hemizygous).
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029124
GBA E326K Knockin Mouse*
Mouse Model
Mouse expressing GBA E326K mutation and 3 silent mutations in exon 8 of the mouse Gba gene. Model was generated and deposited by Mark Cookson at NIH through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036159
GBA1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in GBA1, including heterozygous and homozygous N370S and E326K mutations, among others. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).*Heterozygous and homozygous L444P and Noncoding (rs3115534) mutations are currently in development. Estimated Availability: Q1 2026.
Glucosylceramide Antibody
Antibody
Rabbit monoclonal antibody directed against human/rodent glucosylceramide.
Estimated Availability: Late 2027
GPNMB Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in GPNMB, including knockout heterozygous and homozygous, heterozygous, and homozygous knockout mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP). Estimated Availability: Q1 2026.
GPNMB Protein*
Protein
Human GPNMB Protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
Halo-Tagged LRRK2 MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockin of the Halo tag on the N-terminal of LRRK2.
Expected availability: Early 2026
HdAd5 3xFLAG-LRRK2 (G2019S)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2019S mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (G2385R)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (wild-type)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged WT LRRK2. HdAd5 FLAG-TK available as a control in Control section.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic