Frank P. DiFilippo, PhD

Frank DiFilippo, PhD is Director of Nuclear Imaging Physics in the Cleveland Clinic Department of Nuclear Medicine, where, as a certified nuclear medicine physicist, he oversees camera quality assurance and accreditation and supports clinical operations. His educational and basic research activities are through his faculty appointment in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Although his primary appointment is clinical, Dr. DiFilippo is an active researcher who has served as PI on several NIH grants. 

Dr. DiFilippo serves as the co-director of the NeuroImaging Core of the Cleveland Alzheimer’s Disease Research Center (CADRC, PI: Dr. James Leverenz).  His laboratory performs quantitative analysis of brain amyloid PET, tau PET, and dopaminergic SPECT scans for CADRC NeuroImaging and other collaborations. Brain SPECT analysis is not as well established as PET, due to the less favorable spatial resolution, image quality, and data corrections of SPECT. Dr. DiFilippo looks forward to collaborating with Dr. Roger Gunn to investigate advanced image analysis methods and enhance the impact of the existing SPECT data of the Dementia with Lewy Bodies Consortium.