Professor Huw Morris works on the translational, genetic and pathological aspects of Parkinson’s disease (PD), Fronto-temporal dementia (FTD), Progressive Supranuclear Palsy (PSP) and Corticobasal degeneration (CBD). During his doctoral training, he described tau gene variation in PSP, FTD and the Parkinsonism Dementia Complex of Guam. In Cardiff, he identified the C9ORF72 expansion as the commonest cause of FTD and ALS, in collaboration with Dr Bryan Traynor, and described the epidemiology, clinical features and genetics of early-onset PD. At UCL, he leads a UK-wide longitudinal genetic, imaging and biomarker study of PSP, CBD and atypical parkinsonism, a Europe-wide study of CBD and a study of familial and early-onset PD. He has identified a series of genetic variants (LRRK2, LRP1B, TRIM11/17) related to phenotype and progression of PD and PSP and investigated the relationship between biomarkers and progression.
Associated Grants
-
Leveraging Gene Expression Data to Redefine Parkinson’s Disease and the Pathways Driving Disease in Different Individuals
2023